Clinical Opinion – Poll of the week Poll of week 3Created on April 16, 2023Poll of the Week 7Myeloid leukemia in patients with Down syndrome (ML - DS) originates in utero and typically presents with a self-limiting, neonatal leuke mic syn drome known as transient abnormal myelopoiesis (TAM) that is caused by cooperation between trisomy 21 – associated abnormalities of fetal hematopoiesis and mutations in which of the following? GATA1 GATA2 CRLF2 gene RAS gene Myeloid leukemia in patients with Down syndrome (ML - DS) originates in utero and typically presents with a self-limiting, neonatal leukemic syn drome known as transient abnormal myelopoiesis (TAM) that is caused by cooperation between trisomy 21 – associated abnormalities of fetal hematopoiesis and somatic mutations in N - terminal mutations in the transcription factor GATA1. Around 10 % of neonates with DS have clinical signs of TAM, although the frequency of hematologically silent GATA1 mutations in DS neonates is much higher (~25%). Change/Click on page numbers below for next Question. Pages: 1 2 3 4 5 6 7
