Clinical Opinion – Poll of the week

Poll of week

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Poll of the Week 7

Myeloid leukemia in patients with Down syndrome (ML - DS) originates in utero and typically presents with a self-limiting, neonatal leuke mic syn drome known as transient abnormal myelopoiesis (TAM) that is caused by cooperation between trisomy 21 – associated abnormalities of fetal hematopoiesis and mutations in which of the following?

Myeloid leukemia in patients with Down syndrome (ML - DS) originates in utero and typically presents with a self-limiting, neonatal leukemic syn drome known as transient abnormal myelopoiesis (TAM) that is caused by cooperation between trisomy 21 – associated abnormalities of fetal hematopoiesis and somatic mutations in N - terminal mutations in the transcription factor GATA1. Around 10 % of neonates with DS have clinical signs of TAM, although the frequency of  hematologically silent GATA1 mutations in DS neonates is much higher (~25%).

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