Posaconazole: Prophylaxis and Management of IFIs including significance of TDM

Posaconazole is a second-generation triazole agent with a potent and broad antifungal activity. In addition to the oral suspension, a delayed-release tablet and intravenous formulation with improved pharmacokinetic properties have been introduced recently. It is structurally related to itraconazole and Read More …

MDR Gram Negative Sepsis and CREs

β-lactam antibiotics (beta-lactam antibiotics) are antibiotics that contain a beta-lactam ring in their chemical structure. This includes penicillin derivatives, cephalosporins and cephamycins, monobactams (aztreonam), carbapenems and carbacephems. These β-lactam antibiotics are cornerstone of treatment of gram-negative bacterial (GNB) sepsis. However, Read More …

Waldenstrom’s Macroglobulinaemia Management

Some Salient Points:- Asymptomatic WM cases don’t require emergent treatment and can be followed up. IgM MGUS cases associated with Peripheral Neuropathy (without fitting into WM/IgM MM criteria) require treatment provided other causes of neuropathy has been ruled out by Read More …